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The molecular mechanisms responsible for selective motor neuron loss in SMA remain elusive. Rizzo et al. show that deregulated transcripts in SMA-motor neurons share motif 7, targeted by SYNCRIP, which… Click to show full abstract
The molecular mechanisms responsible for selective motor neuron loss in SMA remain elusive. Rizzo et al. show that deregulated transcripts in SMA-motor neurons share motif 7, targeted by SYNCRIP, which binds SMN. Impaired SYNCRIP-SMN interaction leads to dysregulation of downstream genes, such as NEUREXIN2, which could represent therapeutic targets.
Keywords:
motor neurons;
smn;
rna;
motor;
syncrip;
key role
Journal Title: Brain
Year Published: 2019
Link to full text (if available)
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Journal Title: Brain
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!