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Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response

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Brain calcifications are common in aged individuals, but the mechanisms underlying their formation are unclear. Zarb et al. show that in primary familial brain calcification, a neuropsychiatric disorder featuring bilateral… Click to show full abstract

Brain calcifications are common in aged individuals, but the mechanisms underlying their formation are unclear. Zarb et al. show that in primary familial brain calcification, a neuropsychiatric disorder featuring bilateral vessel-associated calcifications in the basal ganglia, vessel calcification is accompanied by an osteogenic environment which elicits a neurotoxic astrocyte response.

Keywords: brain calcification; primary familial; neurotoxic astrocyte; calcification; brain; familial brain

Journal Title: Brain
Year Published: 2019

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