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Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study

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Imaging biomarkers are needed to detect early brain changes in presymptomatic carriers harbouring FTD mutations. Using arterial spin labelling-MRI, Mutsaerts, Mirza et al. identify an inverse association between cerebral perfusion… Click to show full abstract

Imaging biomarkers are needed to detect early brain changes in presymptomatic carriers harbouring FTD mutations. Using arterial spin labelling-MRI, Mutsaerts, Mirza et al. identify an inverse association between cerebral perfusion in frontotemporoparietal regions and expected age of onset. Cerebral perfusion may be a promising imaging biomarker for presymptomatic genetic FTD.

Keywords: cerebral perfusion; perfusion; presymptomatic genetic; changes presymptomatic; genetic frontotemporal; perfusion changes

Journal Title: Brain
Year Published: 2019

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