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The expanded clinical spectrum of anti-GABABR encephalitis and added value of KCTD16 autoantibodies

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Many patients with anti-GABABR encephalitis respond to immunotherapy, emphasizing the importance of early diagnosis. Van Coevorden-Hameete et al. show that while the majority of patients have epilepsy, others present with… Click to show full abstract

Many patients with anti-GABABR encephalitis respond to immunotherapy, emphasizing the importance of early diagnosis. Van Coevorden-Hameete et al. show that while the majority of patients have epilepsy, others present with progressive dementia without seizures. Adding KCTD16, an auxiliary protein, to a GABABR cell-based assay improves sensitivity without loss of specificity.

Keywords: gababr encephalitis; clinical spectrum; expanded clinical; anti gababr

Journal Title: Brain
Year Published: 2019

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