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Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

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The locus coeruleus is the site of the earliest pathological changes in many neurodegenerative diseases. Betts et al. describe how in vivo locus coeruleus imaging can be used as a… Click to show full abstract

The locus coeruleus is the site of the earliest pathological changes in many neurodegenerative diseases. Betts et al. describe how in vivo locus coeruleus imaging can be used as a biomarker for noradrenergic dysfunction in neurodegenerative diseases, and outline a strategy for achieving reliable and biologically validated imaging approaches.

Keywords: biomarker noradrenergic; neurodegenerative diseases; locus coeruleus; noradrenergic dysfunction; coeruleus imaging

Journal Title: Brain
Year Published: 2019

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