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Objectives A longitudinal analysis was conducted on blood biomarker data from 1032 generally healthy individuals who used an automated, web-based personalized nutrition and lifestyle platform. Methods Combining the power of automation with the concepts of biological and behavioral personalization, we developed an online platform to produce individually customized nutrition and lifestyle recommendations for healthy adults, based on a panel of serum biomarkers. The scalable nature of the platform has allowed us to generate longitudinal biomarker data on 1032 generally healthy adults. Results Biomarker changes during platform use were assessed, showing a trend toward normalcy for most biomarkers in those participants whose values were out of the clinically normal range at baseline. Finally, associations were found between the selection of specific interventions and corresponding biomarker changes, suggesting directions for future study. Conclusions We have used a rich longitudinal dataset of clinical biomarkers to uncover novel biological relationships while validating known ones. Furthermore, we have demonstrated that the personalized health platform described here associates with improvements in health parameters and shows promise for the validation of biomarker-intervention associations in a "real world" setting. By tracking a variety of biomarkers in free-living individuals, this platform provides a novel resource for exploration and hypothesis generation. With the advent of personalized health platforms such as the one described here, new efforts should be devoted to understanding the efficacy of their individual components while incorporating the valuable insights of participants. Funding Sources The scientists who conducted this study are either employed by the sponsoring company or serve as advisors to it. Thus, there is no separation between investigative team and funder, which provided support in the form of salaries, and was involved in the study design, data collection and analysis, decision to publish, and preparation of the manuscript. Supporting Tables Images and/or Graphs