LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Common Brain Cortical Abnormality in Smoking Behavior and Bipolar Disorder: Discriminant Analysis Using Cortical Thickness and Surface Area.

Photo by arunwithideas from unsplash

Cigarette smoking is highly prevalent among patients with bipolar disorder (BD). Structural brain abnormalities related to smoking behavior and BD risk are indicated by magnetic resonance imaging (MRI) studies. However,… Click to show full abstract

Cigarette smoking is highly prevalent among patients with bipolar disorder (BD). Structural brain abnormalities related to smoking behavior and BD risk are indicated by magnetic resonance imaging (MRI) studies. However, cortical alterations common to smoking behavior and BD remain unclear. Our purpose was to identify common cortical alterations between smoking behavior and BD. 3T MRI-based indices of cortical thickness and surface area using FreeSurfer were acquired from 166 healthy control (HC) nonsmokers, 39 HC smokers, 33 BD nonsmokers, and 18 BD smokers. A stepwise discriminant-function analysis (DFA) with cortical structures as predictors was performed to classify BD patients into nonsmokers and smokers. Next, DFAs with the selected structures as predictors were performed to discriminate smoking status or diagnostic status. Differences in the selected features among the four groups were examined. The first DFA showed that six brain features discriminated between nonsmokers and smokers among BD patients. The six brain features related to BD smoking status also discriminated between HCs and BD patients and HC nonsmokers and BD smokers. Among the six features, left insular thickness showed a negative additive effect of smoking status and BD diagnosis. Our findings suggest the common neurobiological involvement of insular thickness in smoking behavior and BDrisk.

Keywords: smoking behavior; cortical thickness; brain; nonsmokers smokers; bipolar disorder

Journal Title: Cerebral cortex
Year Published: 2022

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.