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Influenza has been recognised since the 16th century as an acute respiratory illness that spreads rapidly among communities in outbreaks1. It is typically caused viruses of the Orthomyxoviridae family that… Click to show full abstract
Influenza has been recognised since the 16th century as an acute respiratory illness that spreads rapidly among communities in outbreaks1. It is typically caused viruses of the Orthomyxoviridae family that are divided in Influenza viruses A, B and C2. Influenza A viruses (IAV) have been responsible for seasonal epidemics but also sporadic pandemics resulting from distinct mechanisms of antigenic variation in the surface glycoproteins of the virus, known as antigenic drift and antigenic shift2. Virus replication typically takes place in the respiratory epithelium and causes lung inflammation3. Pneumonia may develop which might be followed by a secondary bacterial infection and in certain cases acute respiratory distress syndrome3.
Journal Title: Cardiovascular research
Year Published: 2020
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