LAUSR

of in non-ST-elevation acute coronary syndrome: a meta-analysis of randomized controlled trials discussion ‘ Timing of invasive strategy in non-ST-elevation acute coronary syndrome: The optimal time for revascularization in patients presenting with non-ST-elevation acute coronary syndrome (NSTE-ACS) has not been determined. The updated European Society of Cardiology guidelines published in 2020 recommend with Class I, level of evidence A an early invasive strategy (IS) within 24 h in patients with a diagnosis of non-ST-elevation myocardial infarction (NSTEMI), dynamic or presum-ably new contiguous ST/T-segment changes suggesting ongoing ischae-mia, transient ST-segment elevation, and Global Registry of Acute Coronary Syndrome (GRACE) risk score ≥ 140. 1 The recently published American College of Cardiology/American Heart Association coronary revascularization guidelines refer to stabilized patients with a high GRACE score of ≥ 140, and give a Class IIA recommendation, level of evidence (B-R) for early IS. 2 The systematic review of randomized controlled trials (RCTs) of early IS for revascularization for this population that was recently published by Kite et al . 3 in the European Heart Journal attempted to address the value of early vs. delayed revascularization. The investigators pooled data from 10 209 subjects who participated in 17 RCTs spanning nearly two decades. By pooling relative risks using a random-effects model, the authors reported that among all-comers