LAUSR

The hypothesis that symptoms of anxiety and depression contribute to the development of arterial hypertension (AH) has been controversial. Mermerelis A. (2016) in pilot study found the association of anxiety disoders with resistant hypertension. Since 2013 social-and-psychological situation, which had developed in Ukraine after beginning of military conflict on the East of the country, has led to the destruction of public consciousness and vital orientation of millions people. Psychoemotional overstrain and psychic disadaptation induced the increasing of level cardiovascular diseases (CVD). But till now, the psychological factor we don't include in the management of hypertensive patient. The prospective study included 596 patients (375 women and 220 men), treated with arterial hypertension in University Clinic, Military Hospital and Cardiological Ambulance of Bukovinian Region. The exclusion criterias were concominant CVD and other somatical diseases in decompensation. Also we didn't include patients with psychiatry disoders. For psychometric screening hospital anxiety and depression scale HADS-A and HADS-D was used. Considering that the data obtained are characterized by asymptomatic normal distribution the Mantel-Henzel factor of disagreement or odds ratio were used. The study under the scheme “case-control” showed that in women OR index stresses significant interrelation of anxiety and level of blood pressure (BP). Thus, the subclinical anxiety at AH 1 degree was according to OR = 1.6 [CI95% - 0.96–2.54). This shows possible association of anxiety and AH at the lower border of the confidential interval. At resistance AH - OR was 3.26 [CI95% - 1.78–5.92], p<0.001. Clinical anxiety is associated with AH due to the index OR in the form of linear dependence, “p” is of high degree of reliability. In men subclinical anxiety is also associated with AH, however “p” value shows reliability only in an estimation of resistance AH at OR 3.45 [CI95% - 1.33–9.57]. The most significant association, both subclinical and clinical anxiety, was noticed at resistance AH both in women 3.1 [CI95% - 1.17–5.2] and men 4.8 [CI95% - 1.93–12.3]. Estimating the value of the relation of chances by association of anxiety and degree of AH in women, it is possible to notice complete comorbidity of anxiety level and arterial hypertension irrespective of their forms and degree. In men association of anxiety level and various clinical degrees of arterial hypertension has its own features, reaching maximum in patients with AH 3 degree and resistance AH. In both women and men clinical form of anxiety often associated with AH 3 degree and resistance AH, so it is necessary to introduce the parameter of the presence of anxiety-depressive syndrome in patients with AH in subclinical and clinical forms.