LAUSR

B2-adrenoreceptors participate in mobilizing fat from fat cells to enable energy production in response to hormones (adrenaline, noradrenaline); they stimulate glycogenolysis in the liver and glucose release into the circulation to replenish energy needs; and enhance glycogen breakdown in skeletal muscles. Glu27 allele is associated with an increased risk of obesity when the diet is rich in carbohydrates. In the 27Glu variant the production of adrenoreceptors is increased, thus increasing sensitivity to beta-agonists; hyperinsulinemia and hypertriglyceridemia can be also observed. In 27Gln variant, on the contrary, beta-agonists production and sensitivity to them are reduced, and increased production and insulin resistance are likely to affect patients with normal body weight. To search for molecular and genetic predictors of metabolic disorders (a combination of protein hypercatabolism (high protein oxidation rate (POR) and decreased oxidation of carbohydrates (low carbohydrate oxidation rate (COR), identified with respiratory indirect calorimetry in the previous studies. The study involved 182 patients with multivessel coronary artery disease and clinical features of coronary artery disease (CAD), requiring surgical myocardial revascularization, and a body mass index of 35.0–50.0 kg/m2. The average age was 59.6±3.5 years old. Frequencies of allele and genotype polymorphism in ADRB2 (27Glu) were analyzed. Multiplicative mode of inheritance “MD−” “MD+” χ2 P OR value 95% Cl ADRB2(27Glu)   Allele C 0.60 0.885 3.56 0.03 0.21 0.05–1.10   AlleleG 0.40 0.115 4.11 0.91–18.76   Genotype C/C 0.40 0.77 3.44 0.03 0.22 0.03–1.22   Genotype C/G 0.50 0.23 3.13 0.56–19.95   GenotypeG/G 0.10 0.00 4.27 0.16–116.34 MD: metabolic disorders (↑POR+↓COR). Our results showed that metabolic changes in obesity may be associated with ADRB2 gene mutation, namely when 27Glu variant is present. Thus, the odds ratio for developing metabolic disorders with G allele was 3.44 times higher (p=0.02, CI (95%) = 1.24 - 19.46), and in patients with genotype G/G - 4.27 times higher (p=0.03, CI (95%) = 15.6 - 199.5). Research No. 0529-2019-0061 Diagnostics, prevention and dietaterapy of patients with alimentary-dependent diseases