LAUSR

Tako-tsubo syndrome (TTS) might be caused by two different trigger mechanisms. There is very little data available on patient characteristics and prognosis regarding the trigger mechanisms. Comparison of patients with TTS in terms of different trigger factor – emotional stress vs. psychical stress caused by severe non-cardiac condition. Data were obtained from the Tako-tsubo registry of patients hospitalized in Cardiocenter University Hospital from 2013 to 2018, in total 86 patients were diagnosed with TTS. The patients were divided into 2 groups according to the triggering cause, that we thoroughly examined in each case. In the first group, there were patients with TTS triggered by emotional stress (such as death in the family or anxiety disorders) and in the second group there were patients whose TTS was caused primarily by non-cardiac conditions of various etiology, such as neurological, infectious or postoperative issues. Out of 86 patients, there were 20 (23,3%) patients excluded, for we weren't able to establish the triggering cause. In 26 (30,2%) patients, the trigger was psychological and 40 (46,5%) patients suffered from non-cardiac condition. According to the collected data there were no significant differences amongst basic demographic facts. Women represented the majority in both groups – 92% vs 95%, age of 70,6±0,8 vs 71,9±0,7 years (p=0,650). There were no significant differences in the hs-TnT 624ng/l ± 49,9 vs 610,2±17,3ng/l (p=0,959). There were significant differences discovered in the average NT-proBNP level – 2691±220,5pg/ml vs 10610±599pg/ml (p<0,05). The patients with non-cardiac conditions developed acute complications more frequently, especially a respiratory failure requiring mechanical ventilation 20% vs 3,8% (p<0,05). In total, 8 (9,3%) patients with TTS died, of whom all had a physical stress factor of p<0,05. Physical stress in patients with severe non-cardiac conditions is a more frequent trigger for TTS than emotional stress. Patients with TTS induced by physical stress have a significantly worse prognosis.