LAUSR

AIMS Studies have shown that symptom perception is associated with fear of progression (FOP) in many diseases and regulated by psychological factors. Whether the association also occurs in patients with chronic heart failure (HF) remains unclear, as do the specific mechanisms involved. This study aimed to explore the multiple mediation effects of self-care confidence and mental resilience on the relationship between symptom perception and FOP in Chinese patients with chronic HF. METHODS AND RESULTS A cross-sectional study was conducted on 247 patients with chronic HF recruited from two hospitals in Yangzhou, China. The sociodemographic and clinical data, and self-reported questionnaires including heart failure somatic perception, fear of progression, self-care confidence and mental resilience were collected. Data analysis relating to correlations and mediating effects was carried out by SPSS 26.0 and PROCESS v3.3 macro. Fear of progression was positively correlated with symptom perception (r = 0.599, p < 0.01), but negatively correlated with self-care confidence (r = -0.663, p < 0.01), mental resilience- strength (r = -0.521, p < 0.01) and mental resilience-toughness (r = -0.596, p < 0.01). The relationship between symptom perception and FOP was mediated by self-care confidence [effect = 0.095, 95% confidence interval (CI) (0.054, 0.142)] and mental resilience-toughness [effect = 0.033, 95% CI (0.006, 0.074)] respectively, and together in serial [effect = 0.028, 95% CI(0.011, 0.050)]. The proportion of the mediating effect accounting for the total effect was 31.0%. CONCLUSIONS Self-care confidence and mental resilience-toughness were multiple mediators of the association between symptom perception and FOP in patients with chronic HF. Interventions targeted at strengthening self-care confidence and mental resilience may be beneficial for the reduction of FOP, especially with regard to toughness.