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On the prospect of achieving accurate joint estimation of selection with population history

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Abstract As both natural selection and population history can affect genome-wide patterns of variation, disentangling the contributions of each has remained as a major challenge in population genetics. We here… Click to show full abstract

Abstract As both natural selection and population history can affect genome-wide patterns of variation, disentangling the contributions of each has remained as a major challenge in population genetics. We here discuss historical and recent progress towards this goal—highlighting theoretical and computational challenges that remain to be addressed, as well as inherent difficulties in dealing with model complexity and model violations—and offer thoughts on potentially fruitful next steps.

Keywords: population history; population; selection population; prospect achieving

Journal Title: Genome Biology and Evolution
Year Published: 2022

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