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Mechanisms of high-level ceftolozane/tazobactam resistance in Pseudomonas aeruginosa from a severely neutropenic patient and treatment success from synergy with tobramycin

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O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(60)-Ib-cr genes in a dog. Antimicrob Agents Chemother 2009; 53: 327–8. 3 Pomba C, L opez-Cerero L, Bellido M… Click to show full abstract

O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(60)-Ib-cr genes in a dog. Antimicrob Agents Chemother 2009; 53: 327–8. 3 Pomba C, L opez-Cerero L, Bellido M et al. Within-lineage variability of ST131 Escherichia coli isolates from humans and companion animals in the south of Europe. J Antimicrob Chemother 2014; 69: 271–3. 4 Pomba C, Rantala M, Greko C et al. Public health risk of antimicrobial resistance transfer from companion animals. J Antimicrob Chemother 2017; 72: 957–68. 5 Johnson JR, Menard M, Johnston B et al. Epidemic clonal groups of Escherichia coli as a cause of antimicrobial-resistant urinary tract infections in Canada, 2002–2004. Antimicrob Agents Chemother 2009; 53: 2733–9. 6 Banerjee R, Robicsek A, Kuskowski MA et al. Molecular epidemiology of Escherichia coli sequence type 131 and its H30 and H30-Rx subclones among extended-spectrum-b-lactamase-positive and -negative E. coli clinical isolates from the Chicago region, 2007 to 2010. Antimicrob Agents Chemother 2013; 57: 6385–8. 7 Féria C, Machado J, Correia JD et al. Virulence genes and P fimbriae PapA subunit diversity in canine and feline uropathogenic Escherichia coli. Vet Microbiol 2001; 82: 81–9. 8 Narciso A, Nunes F, Amores T et al. Persistence of uropathogenic Escherichia coli strains in the host for long periods of time: relationship between phylogenetic groups and virulence factors. Eur J Clin Microbiol Infect Dis 2012; 31: 1211–7. 9 Johnson J. papG alleles among Escherichia coli strains causing urosepsis: associations with other bacterial characteristics and host compromise. Infect Immun 1998; 66: 4568–71. 10 Sabaté M, Moreno E, Pérez T et al. Pathogenicity island markers in commensal and uropathogenic Escherichia coli isolates. Clin Microbiol Infect 2006; 12: 880–6. 11 Can F, Kurt-Azap € O, _ Ispir P et al. The clinical impact of ST131 H30-Rx subclone in urinary tract infections due to multidrug-resistant Escherichia coli. J Glob Antimicrob Resist 2016; 4: 49–52. 12 Kim HB, Wang M, Park CH et al. oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae. Antimicrob Agents Chemother 2009; 53: 3582–4. 13 Liu B, Wu H, Zhai Y et al. Prevalence and molecular characterization of oqxAB in clinical Escherichia coli isolates from companion animals and humans in Henan Province, China. Antimicrob Resist Infect Control 2018; 7: 18. 14 Rodrigues C, Machado E, Fernandes S et al. An update on faecal carriage of ESBL-producing Enterobacteriaceae by Portuguese healthy humans: detection of the H30 subclone of B2-ST131 Escherichia coli producing CTX-M-27. J Antimicrob Chemother 2016; 71: 1120–2. J Antimicrob Chemother 2019; 74: 269–271 doi:10.1093/jac/dky393 Advance Access publication 8 October 2018

Keywords: antimicrob agents; agents chemother; escherichia coli; coli; antimicrob chemother

Journal Title: Journal of Antimicrobial Chemotherapy
Year Published: 2019

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