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AIMS In this study, the effects of SCD Probiotics with TUDCA application on the aged rat gut microbiota (GM) composition were investigated. METHODS AND RESULTS 24 month-old Sprague-Dawley rats were given 300 mg/kg of TUDCA along with 3 mL (1×108 CFU) of SCD Probiotics seven days. The bacterial profile was determined by the metagenome applied to the cecum content. TUDCA, SCD Probiotics, and TUDCA with SCD Probiotics designed GM differently. TUDCA with SCD Probiotics have the most different dominant species profile. CONCLUSIONS SCD Probiotics and TUDCA have their own unique effects on the species found in GM, and when they are evaluated together, the species found in GM are restructured differently.