LAUSR

BACKGROUND Coated Wire Electrodes are considered the most effective and selective type of ion selective electrodes because of the modified surface with different materials according to the substance to be analyzed. OBJECTIVE This study aims to construct the first potentiometric method for analysis of Levocetirizine (LVZ) in its combination form with Montelukast drug. METHOD A novel potentiometric sensor which consists of a silver wire coated with Zinc Oxide (ZnO) nanorod modified with a polymeric membrane combining β-Cyclodextrin and tetraphenyl borate, plasticized with di-butyl phthalate was constructed for the determination of Levocetirizine.2HCl in its pure form and its combination dosage form. RESULTS The fabricated sensor exhibited a linearity range (5x10 -6- 1x10-2) mol/L with a Nernstian slope 57.88 mV/decade, over pH range (2-4.5), the effect of the temperature on the constructed sensor was studied and it was found that the electrode works effectively over (10-50) C°. The electrode showed a fast response time and the lifetime of the electrode was found to be 72 days without significant change in the Nernstian slope value. The selectivity of the electrode toward levocetirizine was estimated in the presence of some obstructive ions. CONCLUSIONS The method was validated according to ICH rules and applied to the determination of levocetirizine in its pure and combined pharmaceutical dosage forms. HIGHLIGHTS This paper introduces the synthesis of the first modified Coated Wire Electrode with ZnO Nanorods for determination the Levocetirizine drug.The obtained results demonstrate the ability of the electrochemical methods to analyze drugs in their combination. The presented method excels over another analytical methods in terms of sensitivity, selectivity and simplicity.