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Human monocyte-derived dendritic cells (moDCs) develop from monocytes play a key role in innate inflammatory responses as well as T-cell priming. Steady-state moDCs regulate immunogenicity and tolerogenicity by changing metabolic… Click to show full abstract
Human monocyte-derived dendritic cells (moDCs) develop from monocytes play a key role in innate inflammatory responses as well as T-cell priming. Steady-state moDCs regulate immunogenicity and tolerogenicity by changing metabolic patterns to participate in the body's immune response. Increased glycolytic (Gly) metabolism after danger signal induction may strengthen moDCs' immunogenicity, whereas high levels of mitochondrial oxidative phosphorylation (OXPHOS) were associated with the immaturity and tolerogenicity of moDCs. In this review, we will discuss what is currently known about differential metabolic reprogramming of human moDCs development and distinct functional properties.
Journal Title: Journal of leukocyte biology
Year Published: 2023
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