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The 2019-2020 dengue fever epidemic: genomic markers indicating severity in Dominican Republic children.

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We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. 488 participants had serologically confirmed DF. We… Click to show full abstract

We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. 488 participants had serologically confirmed DF. We replicated the association between IFIH1 gene (rs1990760) and severe DF (n=80/488, p=0.006) and identified novel associations needing further investigation.

Keywords: 2020 dengue; dominican republic; epidemic genomic; 2019 2020; fever epidemic; dengue fever

Journal Title: Journal of the Pediatric Infectious Diseases Society
Year Published: 2022

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