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Abstract We conducted a phase I clinical trial of an experimental live attenuated recombinant human metapneumovirus (HMPV) vaccine (rHMPV-Pa) sequentially in adults, HMPV-seropositive children, and HMPV-seronegative children, the target population… Click to show full abstract
Abstract We conducted a phase I clinical trial of an experimental live attenuated recombinant human metapneumovirus (HMPV) vaccine (rHMPV-Pa) sequentially in adults, HMPV-seropositive children, and HMPV-seronegative children, the target population for vaccination. rHMPV-Pa was appropriately restricted in replication in adults and HMPV-seropositive children but was overattenuated for HMPV-seronegative children.
Keywords:
attenuated human;
evaluation live;
live attenuated;
vaccine;
human metapneumovirus
Journal Title: Journal of the Pediatric Infectious Diseases Society
Year Published: 2018
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Journal Title: Journal of the Pediatric Infectious Diseases Society
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!