LAUSR

Ubiquitination is one of the best known post-translational modifications in eukaryotes, in which different linkage types of polyubiquitination result in different outputs of the target proteins. Distinct from the well-characterized K48-linked polyubiquitination that usually serves as a signal for the target protein degradation, K63-linked polyubiquitination often requires a unique E2 heterodimer Ubc13-UEV and alters the target protein activity instead of degradation. This review focuses on recent advances on roles of Ubc13-UEV mediated K63-linked polyubiquitination in plant growth, development and response to environmental stresses.