LAUSR

Abstract S5.4 Free oral paper session, September 22, 2022, 3:00 PM - 4:30 PM Objectives Analysis of the cutaneous manifestations in patients with deep fungal infections to provide a basis for clinical differentiation and diagnosis. Method Patients who presented to our hospital from 2016 to 2021, were definitively diagnosed with deep fungal infections by histopathology and mycological detection. Isolates of focal infections were cultured in vitro on SDA or MEA media for 14 days and the species were identified by morphological or molecular analysis. Relevant clinical data on epidemiologic, skin manifestations, underlying disease, causative fungal agent, treatment, and outcomes are collected and analyzed. Results A total of 15 patients were diagnosed with deep fungal infections. The respiratory system (7/15) was the most easily involved primary focus of deep fungal infection, digestive system (3/15), and nervous system (2/15) were less common. The mean age of the patients was 50.30 years. Of these, 8 were males. More than half of the cases (7/15) were presented in immunosuppressed patients, including long-term glucocorticoid use, organ transplantation, tuberculosis infection, and malignancy. Skin manifestations were varied, with plaques (5/15) being the most common type of lesion, and then papules (4/15), nodules (2/15), patches (2/15), and ulcers (2/15). Candida spp. (9/15) was the most common pathogens, followed by Talaromyces marneffei (2/15) (Fig. 1a), Cryptococcus spp. (2/15) (Fig. 1b), and Aspergillus spp. (2/15). One case had co-infection with C. albicans and Aspergillus spp. Conclusions Patients with deep fungal infections are often accompanied by skin manifestations, which vary between patients with deep fungal infections caused by different pathogenic fungi.