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SP567ASSOCIATION BETWEEN AGE AND CHANGES IN HEART RATE VARIABILITY AFTER HEMODIALYSIS IN PATIENTS WITH DIABETES

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RESULTS: Our study included 37 hemodialysis patients and 34 peritoneal dialysis (PD) patients with a median age of 59.0 years and a median myostatin level of 4991.4 pg/mL. Patients with… Click to show full abstract

RESULTS: Our study included 37 hemodialysis patients and 34 peritoneal dialysis (PD) patients with a median age of 59.0 years and a median myostatin level of 4991.4 pg/mL. Patients with low myostatin levels were older and had a higher proportion of men and PD than those with high myostatin levels. The proportion of patients with AAC score 5 was significantly higher in patients with low myostatin levels than those with high myostatin levels, however, HP score 3 and the presence of feet calcification were no significantly different in both groups. The median myostatin level for patients with AAC scores 5 was 4073.5 pg/mL, whereas that for AAC scores<5 was 5838.6 pg/ mL. Age and AAC scores showed a significantly negative correlation with myostatin levels. Lower myostatin levels were independently associated with higher AAC scores after adjustment for age, gender, DM, dialysis vintage, dialysis modality, and osteoprotegerin levels.

Keywords: myostatin; age; myostatin levels; aac scores; hemodialysis patients

Journal Title: Nephrology Dialysis Transplantation
Year Published: 2018

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