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An Epidemiology Report for Primary Central Nervous System Tumors in Adolescents and Young Adults: a nationwide population-based study in France, 2008-2013.

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BACKGROUND Primary central nervous system tumors (PCNST) among adolescents and young adults (AYA, 15-39 years) have rarely been reported. We present a nationwide report of PCNST histologically-confirmed in the French… Click to show full abstract

BACKGROUND Primary central nervous system tumors (PCNST) among adolescents and young adults (AYA, 15-39 years) have rarely been reported. We present a nationwide report of PCNST histologically-confirmed in the French AYA population between 2008 and 2013. METHODS Patients were identified through the French Brain Tumor Database (FBTDB), a national dataset that includes prospectively all histologically-confirmed cases of PCNST in France. Patients aged 15 to 39 years with histologically-confirmed PCNST diagnosed between 2008 and 2013 were included. For each of the 143 histological subtypes of PCNST, crude rates, gender, surgery and age distribution were provided. To enable international comparisons, age-standardized incidence rates were adjusted to the world-standard, European and USA populations. RESULTS For six years, 9661 PCNST (males/females: 4701/4960) were histologically confirmed in the French AYA population. The overall crude rate was 8.15 per 100,000 person-years. Overall, age-standardized incidence rates were (per 100,000 person-years, population of reference: world/Europe/USA): 7.64, 8.07, and 8.21. Among patients aged 15-24 years, the crude rate was 5.13 per 100,000. Among patients aged 25-39 years, the crude rate was 10.10 per 100,000. Age-standardized incidence rates were reported for each of the 143 histological subtypes. Moreover, for each histological subtype, data were detailed by gender, age, type of surgery (surgical resection or biopsy) and cryopreserved samples. CONCLUSION These data represent an exhaustive report of all histologically-confirmed cases of PCNST with their frequency and distribution in the French AYA population in 2008-2013. For the first time in this age group, complete histological subtypes and rare tumors identification are detailed.

Keywords: histologically confirmed; age; report; epidemiology; 2008 2013; population

Journal Title: Neuro-oncology
Year Published: 2019

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