LAUSR

BACKGROUND Delayed cerebral ischemia (DCI) is a cause of poor outcome after aneurysmal subarachnoid hemorrhage. Risk scales to predict DCI have scarcely been evaluated for predictive accuracy. Accounting for volume of intraventricular hemorrhage (IVH) in the modified Fischer scale (mFS) may improve its predictive accuracy. OBJECTIVE To compare the modified Graeb score (mGS) to the mFS for risk prediction of DCI, and to investigate whether incorporating an mGS cut-point into the mFS could improve predictive accuracy. METHODS This retrospective analysis was based on the Clazosentan to Overcome Neurological Ischemia and Infarction Occurring after Subarachnoid Hemorrhage (CONSCIOUS-1) trial cohort. IVH volume was quantified with the mGS. The relation of the mGS to DCI was evaluated using logistic regression and the area under the receiver operator characteristics curve (AUC). An optimized mGS cut-point was identified using the Youden index, and was incorporated into the mFS to dichotomize grades 2 and 4. The AUC was used to compare the predictive performance of the mGS with that of the mFS, and to assess whether there was an improvement in DCI prediction after creation of the dichotomized scale. RESULTS The mFS and the mGS had similar discrimination for DCI (AUC: 0.608 vs 0.618; P = .79). A new scale including both the mFS and mGS significantly improved the AUC compared to the mFS (AUC: 0.647 vs 0.608; P = .022). CONCLUSION The mFS and the mGS have similar prognostic utility. Accounting for IVH volume improved prediction of DCI by the mFS.