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TARGET POPULATIONS Adults with solid brain metastases who have not experienced a seizure. QUESTION 1 Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain… Click to show full abstract
TARGET POPULATIONS Adults with solid brain metastases who have not experienced a seizure. QUESTION 1 Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free? RECOMMENDATION Level 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free. QUESTION 2 Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting? RECOMMENDATION Level 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended.The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatment-adults-metastatic-brain-tumors/chapter_8.
Journal Title: Neurosurgery
Year Published: 2019
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