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Abstract Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose Clostridioides difficile infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic… Click to show full abstract
Abstract Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose Clostridioides difficile infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic C. difficile carriers. Thirty-nine percent of specimens from asymptomatic carriers were positive. Thus, CCNA specificity may be lower than previously thought.
Keywords:
neutralization assay;
clostridioides difficile;
cell cytotoxicity;
cytotoxicity neutralization;
difficile carriers
Journal Title: Open Forum Infectious Diseases
Year Published: 2021
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Journal Title: Open Forum Infectious Diseases
Year Published: 2021
Link to full text (if available)
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recommendations!