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Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male

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Abstract We present a case of a human immunodeficiency virus–negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically… Click to show full abstract

Abstract We present a case of a human immunodeficiency virus–negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. Syphilis was diagnosed after tissue obtained from a brain biopsy demonstrated spirochetes consistent with Treponema pallidum and confirmed by 16S ribosomal RNA sequencing.

Keywords: syphilis presenting; mass; brain mass; meningovascular syphilis; presenting brain; brain

Journal Title: Open Forum Infectious Diseases
Year Published: 2021

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