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Abstract Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12–interferon gamma signaling pathway. We investigated… Click to show full abstract
Abstract Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12–interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-α-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies.
Keywords:
traf3;
infection;
traf3 variant;
negative traf3;
dominant negative;
recurrent
Journal Title: Open Forum Infectious Diseases
Year Published: 2022
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Journal Title: Open Forum Infectious Diseases
Year Published: 2022
Link to full text (if available)
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recommendations!