LAUSR

Abstract Background Mortality for people living with HIV (PLWH) has drastically decreased since the mid-1990s, and the proportion of deaths due to non-HIV-related conditions has increased. Methods Deceased PLWH were identified within a single academic medical center. Cause of death was determined by chart review, clinic providers, and when available autopsy and toxicology data. Chart review of comorbidities, demographics and preventable causes of cancer was conducted for deaths during the period of 2013–2017. Results The proportion of AIDS-related deaths decreased markedly between 1995 and 2017, while the proportion of deaths from non-AIDS cancers has increased (figure). Patients with non-AIDS cancers were older, had a higher CD4 count and greater proportion with undetectable viral load, and were more likely to be male; over 80% were current or prior smokers (table). Among all deaths from 2013 to 2017, 44% of eligible patients received colon cancer screening, 66% received cervical cancer screening, and 29% received breast cancer screening. Of patients who died from HCC, one out of six had imaging for HCC within 1 year and none within 6 months of diagnosis. Conclusion Improvements in cancer screening and preventative health measures including smoking cessation and lifestyle improvement education may help to reduce the increasing proportion of non-AIDS cancer-related deaths among PLWH. Characteristics by Cause of Death (2013–2017) HIV-Related Cancer ‡ P-value N 22 24 Age at death 50 (44, 56) 56 (53, 61) 0.03 Last available CD4 72(15, 249) 207(94, 301.5) 0.02 Last available viral load < 50 copies 5 (23) 16 (67) 0.004 CD4 Nadir 18(7, 110) 77(35, 126) 0.2 Male 14 (64) 23 (96) 0.009 Smoking within 1 year of death 9 (41) 13 (54) 0.8 Smoking, quit 1-15 years prior to death 5 (23) 6 (25) Smoking, quit > 15 years prior to death 1 (5) 1 (4) Never smoked 7 (32) 4 (17) *Median (IQR) or n (%). ‡ Most common: HCC (6), head/neck (4), prostate (3). Disclosures All authors: No reported disclosures.