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Multiplicity of Infection Is a Poor Predictor of Village-Level Plasmodium vivax and P. falciparum Population Prevalence in the Southwest Pacific

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Abstract Across 8101 individuals in 46 villages, the proportion of Plasmodium spp. multiple clone infections (0%–53.8%) did not reflect prevalence by quantitative polymerase chain reaction (qPCR; 1.9%–38.4%), except for P.… Click to show full abstract

Abstract Across 8101 individuals in 46 villages, the proportion of Plasmodium spp. multiple clone infections (0%–53.8%) did not reflect prevalence by quantitative polymerase chain reaction (qPCR; 1.9%–38.4%), except for P. vivax in Solomon Islands (P < .001). Thus this parameter was not informative to identify transmission foci. In contrast, prevalence by microscopy and qPCR correlated well.

Keywords: multiplicity infection; prevalence; infection poor; plasmodium; predictor village; poor predictor

Journal Title: Open Forum Infectious Diseases
Year Published: 2018

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