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Acute Toxoplasma Dissemination With Encephalitis in the Era of Biological Therapies

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Abstract We report the case of a 65-year-old patient with pseudolymphoma who developed acute toxoplasmosis following 6 cycles of rituximab and bendamustine therapy. Acute toxoplasmosis in the setting of biological… Click to show full abstract

Abstract We report the case of a 65-year-old patient with pseudolymphoma who developed acute toxoplasmosis following 6 cycles of rituximab and bendamustine therapy. Acute toxoplasmosis in the setting of biological response modifiers, rather than reactivation, is a unique unreported infection. The patient developed severe disease with multi-organ involvement, including retinitis, myocarditis, and myositis. We discuss the clinical findings, epidemiology, and laboratory diagnosis.

Keywords: era biological; dissemination encephalitis; acute toxoplasma; toxoplasma dissemination; encephalitis era; biological therapies

Journal Title: Open Forum Infectious Diseases
Year Published: 2018

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