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P2X7 is an ionotropic receptor activated by extracellular ATP which is expressed on immune cells including macrophages, dendritic cells and lymphocytes and is up-regulated on non-immune cells following injury. P2X7… Click to show full abstract
P2X7 is an ionotropic receptor activated by extracellular ATP which is expressed on immune cells including macrophages, dendritic cells and lymphocytes and is up-regulated on non-immune cells following injury. P2X7 has previously been shown to be important in inflammation and fibrosis, and may also play a role in autoimmunity. However, recent studies have shown both strains of P2X7 deficient mice are incomplete knockouts and have generated conflicting results. Therefore, we have assessed the importance of P2X7 in autoimmunity and glomerulonephritis (GN) using a novel P2X7 knockout (KO) rat.
Journal Title: Rheumatology
Year Published: 2019
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