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Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre

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Abstract Background Leishmaniasis is a neglected tropical disease that is imported by travellers returning to the UK. Given the prolonged therapy required, outpatient treatment has been proven to be cost-effective… Click to show full abstract

Abstract Background Leishmaniasis is a neglected tropical disease that is imported by travellers returning to the UK. Given the prolonged therapy required, outpatient treatment has been proven to be cost-effective and safe. Methods We describe cases of leishmaniasis treated through outpatient parenteral antimicrobial therapy (OPAT) over a 13-y period (March 2006–September 2018) at a large teaching hospital. Results A total of 26 episodes of leishmaniasis were treated successfully, with a mean saving of 14.2 bed-days/episode. Sodium stibogluconate was the most used antileishmanial (92%). Conclusions Treatment of chronic infections via OPAT is now commonplace and this approach may be considered for other imported infectious diseases.

Keywords: infectious diseases; therapy; parenteral antimicrobial; leishmaniasis; outpatient parenteral; antimicrobial therapy

Journal Title: Transactions of the Royal Society of Tropical Medicine and Hygiene
Year Published: 2023

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