LAUSR

Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: Neuro-functional morbidity occurs in ~30% of PICU survivors, and young children may be at particular risk. Bronchiolitis is a common indication for PICU admission among young children, but contemporary data of post-PICU neurofunctional morbidity of bronchiolitis patients are lacking. We hypothesized that survivors of critical bronchiolitis would have less favorable scores on a developmental screening tool compared to published normative values. Methods: With IRB approval, we mailed a common developmental screening tool – the Ages and Stages Questionnaire (ASQ) – to parents of children who were previously admitted to our PICU between 1/2015 and 3/2017 with a primary diagnosis of bronchiolitis. Demographics, pre-existing co-morbid conditions, and use of mechanical ventilation (MV) and high flow nasal cannula (HFNC) were extracted from the medical record. For each of the five domains that are included in the ASQ (each with a maximum score of 60), the respondents’ data were compared to normal values using a one-sample t test. Sub-groups were compared with Wilcoxon rank sum. Data are shown as mean (SD) and median (IQR). Results: Of the 349 ASQs mailed, 51 (14.6%) completed ASQ forms have been returned and analyzed. Among these 51 children, median age at admission was 4 (2–8.5) months, 32 (62.7%) were male, 32 (62.7%) were Caucasian, and 20 (39.2%) had co-morbidities. MV was used in 10 (19.6%) subjects and HFNC in another 33 (64.7%) subjects. Compared to the published average scores for a 20mo child (the median age at the time of ASQ completion), the study cohort had significantly less favorable scores in all five domains: Communication (42.26 [17.76] vs. 48.14, p = 0.022), Gross Motor (44.61 [18.05] vs. 55.82, p < 0.001), Problem Solving (42.16 [17.76] vs. 52.73, p < 0.001), Personal-Social (42.55 [16.69] vs. 48.24, p = 0.018), and Fine Motor (42.16 [14.94] vs. 52.04, p < 0.001). Median scores were lower for subjects requiring MV/ HFNC vs. others for all five domains, reaching statistical significance in Problem Solving (40 [30–50] vs. 60 [50–60], p = 0.026) and Personal-Social (40 [35–55] vs. 60 [46.25–60], p = 0.016). Conclusions: These preliminary data support that children who previously required PICU admission for bronchiolitis may have abnormal development. Future studies are needed to more thoroughly measure chronic neuro-functional morbidity among survivors of critical bronchiolitis and identify modifiable risk factors.