LAUSR

Objective: Inflammation and immunosenescence (IS) have been considered to be associated with hypertension. (HTN) Obstructive sleep apnea (OSA) was also associated with chronic inflammation by repetitive oxidative stress. However, the relationship between immunosenecenece parameters and treatment of HTN with or without OSA is unclear. We evaluate to demonstrate the association of chronic inflammation and IS parameters with OSA in hypertensive patients and the changes according to BP treatment. Design and method: Multicenter longitudinal observational study from April 2013 to October 2015. A total of 131 Hypertensive patients (SBP>140 mm Hg or DBP>90 mm Hg) were devided into OSA low risk and OSA high risk according to Berlin sleep apnea questionnaire. CD28 null and CD58 (+) fraction of CD8 T-cells were sampled at baseline in both groups. 87 patients among them were analyzed for baseline and 6 months follow-up immunosenescence parameters with treatment of HTN. Results: Among 131 subjects, 88 patients (67.2%) were OSA high risk, and 43 patients (32.8%) were OSA low risk. CD28 null fraction of CD8 T cells in OSA high risk group was 35.1 ± 18.3% vs 43.9 ± 19.9% in low risk group with a p-value 0.014. CD58+ fraction of CD8 T-cells in OSA high risk group was 37.0 ± 16.9% vs 44.7 ± 20.0% in OSA low risk group with a p-value 0.023. HTN was controlled in 56 patients (64.4%). CD28nullCD8+ T cell was significantly decreased from 41.1 ± 17.9% to 37.5 ± 18.8% (p-value=0.01) but CD57+CD8+ T cell was not correlated with HTN treatment. (42.2 ± 17.5% vs 42.7 ± 18.4%, p-value = 0.596). In multivariate analysis, only age was associated with change in CD28nullCD8+ T cell with greater reduction in CD28nullCD8+ T cell. (beta: 0.373, t = 2.412, p-value = 0.019). Conclusions: CD28 null and CD58 (+) fraction of CD8 T-cell in hypertensive patients with OSA were paradoxically higher in patients without OSA. IS parameter, CD28nullCD8+ T cell was significantly decreased with HTN treatment, especially in younger patients.