LAUSR

Objectives: To confirm whether the blood pressure variation rate is a risk factor for cognitive decline in elderly patients with hypertension, this meta-analysis provides a basis for improving the cognitive function of hypertension in elderly patients. Methods: “blood pressure variation rate”, “cognition” and “hypertension” as inscription, retrieval Pubmed, Cochrane Library, Embase and Web of science to find the correlated observational studies and track the reference of related articles. Revman 5.3.0 software had a meta-analysis on the correlation between blood pressure variation rate and cognitive function in elderly patients with hypertension. Results: Thirteen observational studies with a total of 12611 cases of elderly patients with hypertension were enrolled. Seven studies used the Mini-Mental State Examination (MMSE) scale, and other studies used other cognitive function scales to assess cognitive function. The results show that the systolic blood pressure variation rate and cognitive function decline were significantly correlated in elderly patients with hypertension (OR, 1.747 [1.25, 2.44], P < 0.01); There was no correlation between diastolic pressure variation rate and cognitive function decline (OR, 0.912 [0.81, 1.03], P > 0.05). After adjustment for age and other factors, higher blood pressure variation rate was significantly associated with lower MMSE score (P < 0.01). The blood pressure variation rate of the no blood pressure control group was higher than the blood pressure control group (P < 0.05). Conclusion: There was a significant correlation between cognitive dysfunction and systolic blood pressure variation in elderly patients with hypertension. Systolic pressure variation is an independent risk factor for cognitive decline in elderly patients with hypertension.