LAUSR

Objectives: We investigated the relationship between abnormal metabolic conditions and arterial stiffness in hypertensives. Methods: A total of 680 subjects (age 58.44 ± 11.67 years, male 63.53%, hypertension 65.00%) enrolled in the studies was divided into five groups based on the number of known components of metabolic syndrome according to the criteria of 2010 Chinses Guidelines for Prevention and Management of Hypertension (0MS: n = 86; 1MS: n = 153;. 2MS: n = 201;.3MS: n = 148;. 4/5MS: n = 92.). Body weight, height, waist circumference, hip circumference, blood pressure and biochemical markers were measured. Carotid-femoral pulse wave velocity (cfPWV) was measured using a non-invasive automatic device. Results: The level of cfPWV was significantly increased with the increase of the number of abnormal metabolic components even after adjustments for age, gender (8.20 ± 1.54 vs 8.72 ± 1.48 vs 9.34 ± 1.77 vs 9.64 ± 1.86 vs 9.91 ± 2.19 m/s, P < 0.05). Subjects with hypertension (n = 442) had higher cfPWV than in subjects without hypertension (n = 238) after adjustments for age, gender and blood pressure.(9.59 ± 1.90 vs 8.49 ± 1.50 m/s, P < 0.05). Stepwise multiple regression analysis revealed that age, gender, blood pressure, heart rate as well as the serum uric acid level of the subjects were influent factors for cfPWV (P < 0.05). In the subgroups based on age, the prevalence of hypertension could make the influence of systolic blood pressure on arterial stiffness happen in advance (nonhypertensive in 60 years old, hypertensive in 50 years old). Conclusion: The arterial stiffness increased with the increasing of the abnormal metabolic component numbers, which is independent of age, gender and blood pressure. And the prevalence of hypertension could make the influence of systolic blood pressure on arterial stiffness happen in advance.