LAUSR

Objectives: To investigate the relationship between serum inflammatory cytokines such as IL-6, IL-8, IL-4, IL-10, LPO and Hcy in hypertensive patients with acute coronary syndrome. Methods: A total of 118 hypertensive patients with ACS were enrolled. According to the results of coronary angiography, they are divided into four groups, 50 patients with three branches of coronary artery lesions, two branches lesion in 39 patients, 29 patients with one branch of coronary artery lesions, and 29 patients with normal coronary angiography. Double antibody sandwich enzyme linked immunosorbent assay (ELISA) to detect serum levels of IL-4, IL-6, IL-8, IL-10, LPO, and homocysteine (Hcy). Results: Serum levels of IL-4, IL-6, IL-8, IL-10, LPO and Hcy in ACS patients were significantly higher than those in the control group. Compared with one-vessel lesion group, the serum of IL-4, IL-6, IL-8, IL-10, LPO and Hcy were significantly increase in two and three branches lesions groups.While compared with two vessel disease group, three vessel lesion group were also significantly increased (all P vaule < 0.05). Correlation analysis showed that the serum level of Hcy was positively correlated with severity of the stenosis and the more number of coronary artery lesions (r = 0.934, p < 0.05 and r = 0.934, p < 0.05). Conclusion: Hcy is an independent risk factor for hypertensive patients with ACS. Hypertension patiens with high homocysteine levels had more severe and number of coronary artery lesions.