LAUSR

Objectives: We aimed to investigate the sex-specific association of childhood blood pressure (BP) with adult renal damage and function. Methods: Data were obtained from a population-based cohort of children aged 6–18 years started in 1987. The study comprised 936 subjects who were followed up in 2014 (aged 32–46 years). Renal Damage was assessed using urine albuminuria/creatinine ratio (ACR), and renal function using serum creatinine-based glomerular filtration rate (GFR). Results: Childhood SBP was significantly associated with adult ACR in males (&bgr; = 0.60, P = 0.002) but not in females (&bgr; = 0.03, P = 0.830), adjusted for age, follow up duration, and adult BMI, diabetes, and other risk factors. After further adjustment for adult SBP, the association of childhood SBP with adult ACR was still significant in males. In addition, childhood SBP was not associated with adult GFR with or without adjustment for covariates for both males and females. Conclusion: Childhood elevated BP predicts adult renal damage only in males but not in females. These findings underscore the importance of early prevention of elevated BP to reduce future risk of renal disease, especially in males.