LAUSR

Objectives: Volume overload (VO) associates with the pathogenesis of hypertension and acts important roles in senile hypertension. Our aim is to investigate the prevalence of VO among hypertensive outpatients. Methods: We enrolled 515 hypertensive outpatients without pregnancy or conductive medical apparatus from the Third Affiliated Hospital, Sun Yat-sen University. VO were measured using bioimpedance analysis equipment(identify ECW/TBW≥0.39 as VO). Other baseline data such as age, gender, weight, height and BP were obtained from a standard questionnaire and physical measurements. Chi-square test and Spearman correlation analysis were performed to analyze the influencing factors. Results: Among 515 hypertensive outpatients(217 males, 298 females, age 55.8 ± 14.7), 109 patients (21.17%, 33 males, 76 females, age 65.3 ± 14.3) were identified as VO. Compared with those without VO(184 males, 222 females, age 53.3 ± 13.7), there was a higher ratio of female gender(69.7% vs 54.6%, P = 0.005), higher systolic blood pressure (149.6 ± 18.0 vs 144.2 ± 15.4, P = 0.005) and lower prevalence rate of diabetes (51.4% vs 65.5%, P = 0.007) in patients with VO. Patients with VO had significant lower percentage of overweight (27.5% vs 48.0%, P < 0.001), excess body fat (50.4% vs 61.8%, P = 0.032) and exceeded BMI (33.9% vs 56.1%, P < 0.001). VO correlated positively with age and systolic blood pressure in patients with VO. Conclusion: Hypertensive patients with VO need to be identified early as its considerable proportion in patients with hypertension. Interventions to reduce VO should be considered in senile hypertension.