LAUSR

Objectives: To reveal informative and sensitivity of laser correlation spectrometry as screening method in elderly with arterial hypertension (AH) II, III stage in combination with coronary artery disease (CAD) before treatment. Methods: 107 patients with abovementioned comorbid pathology were examined at therapeutical department at University Clinic (Odessa, Ukraine) according to ESC recommendations. Their average age was 65.5 ± 5.6 years. They were divided into 2 groups: in group I were included patients with AH II stage with CAD (n = 49); group II consisted of patients with AH III stage with CAD (n = 58). Special investigation method – laser correlation spectrometry (LCS). Blood serum was an investigated biomaterial. Results: In both groups was revealed hypercholesterolemia (7.3 and 7.2 mmol/l). Ejection fraction was lower in IInd group than in Ist (53.5 vs 64.5%). In LCS data of the Ist group anabolic type was prevailing (47.0%) among other homeostatic shifts and 11–150 nm particles were prevailing in subfractional redistribution (p < 0.05). In the IInd group hydrolytic type was most expressed (44.0%) and 11–30 nm particles were prevailing (48.2%). Prevalence of 11–30 nm particles in the IInd group, which presented with low density lipoproteins (LDL), points on more severe damage of target organs in patients with AH III stage. Conclusion: Presence of particles 11–30 nm in both groups reflect common pathogenesis of AH II, III and CAD – atherosclerosis. LCS allows to differentiate stages of AH which shows high sensitivity and informative of method.