LAUSR

Objectives: To determine possibilities of spiroarteriocardiorhythmograpy (SACR) as clinical pharmacology method in correction of antihypertensive pharmacotherapy efficacy Methods: 230 patients were examined and treated at the department of internal medicine of Odessa medical university (Ukraine) from 2013–2017 according to ESC guides. Their mean age was 57.7 ± 6.7 years. They were divided into 3 groups: 65 patients with arterial hypertension (AH) I stage (group I), 85 with AH II stage (group II) and 80 with AH III stage (group III). Special investigation method – SACR. Results: Total power (TP) of variability signal decreased gradually from group I to group III: 967.2 msec2 (384.2; 1551) vs 510.8 msec2 (331.6; 697.0). High frequency (HF) component is significantly lower in group III than in group I: 104.1msec2 (48.2; 190.4) vs 441.0 msec2 (127.7; 979.7). Low frequency (LF) and HF ratio revealed that it decreased from group I to group III. TP of systolic blood pressure (SBP) increased from group III to group I (23.9 vs 21.2 mmHg). TP of diastolic blood pressure (DBP) showed that the biggest rate was in group II in comparison with groups III and I: 9.6 > 6.3 > 5.3 mmHg. Baroreflex (BR) LF is the biggest in group II in comparison with groups I and III: 6.9 > 4.9 > 3.1 msec/mm Hg. BRHF is also the most prominent in group II in comparison with groups I and III: 8.2 > 7.2 > 7.1 msec/mm Hg. Conclusion: Usage of &bgr; adreno-blockers, ACE-inhibitors, angiotensin II receptor blockers can be efficient in patients with high TP SBP and TPDBP. When the patient has low rates of rigid heart rhythm it is recommended to avoid drugs with negative dromotropic effect (&bgr; adreno-blockers, glycosides, antiarrhythmic drugs). When on ECG is revealed prolonged conduction - &bgr; adreno-blockers, glycosides, potassium and magnesium drugs should be excluded.