LAUSR

Objectives: To explore the relationship between the number of metabolic syndrome (MS) components and early renal damage. Methods: A total of 399 consecutive untreated middle-aged hypertensive patients with normal renal function were included in the cross-sectional study. Patients with MS were included in MS group (n = 246) and patients without MS were in non-MS group (n = 153). Comparison was made between two groups and relationship between the number of MS and early renal damage. Results: 1. Body mass index, diastolic blood pressure (DBP), urinary microalbuminuria-to-creatinine ratio (ACR) and TG, HDL, creatine and uric acid, were significantly increased in MS group, but eGFR was significantly reduced (P < 0.05); 2. In MS group, ACR raised gradually with the increasing number of MS components, and reached the highest value when MS was with 5 components (P < 0.05); 3. Impaired fasting glucose, elevated TG levels and blood pressure grade were the risk factors for early renal injury in hypertensive patients. However, after adjusting for age and gender, impaired fasting glucose (IGF), increased TG, and blood pressure grading were significantly associated with early renal damage (OR = 1. 852, 3. 622 and 1. 6, P < 0.05). Conclusion: MS components were significantly associated with early renal damage in hypertension, which became stronger as MS components increased. MS with 3 components was marked as a critical point for compensation period of glomerular filtration. IGF, increased levels of glycerides and higher grades of blood pressure are independent risk factors for early renal damage in hypertension.