LAUSR

Objectives: To explore the relation of coronary atherosclerotic heart disease and cognitive impairment in elderly hypertensive patients. Methods: A total of 78 hypertensive patients with coronary atherosclerotic heart disease from October 2016 to October 2017 were taken as observation group, and 49 hypertensive patients as the control group. Compared the differences of sex, age, occupation, diet and sleep, smoking history, drinking history, history of diabetes, history of hypertension, body mass index (BMI), total cholesterol (CHO), triacylglycerol (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and other related levels in two groups. The mini-mental state examination (MMSE) score were used to assessed cognitive function. For those patients with cognitive impairment, The Montreal cognitive assessment (MoCA) were used to assessed cognitive impairment domains. Results: The average score of MMSE in patients with coronary atherosclerotic heart disease was not significantly different from those in control group (P > 0.05), but the incidence of mild cognitive impairment was higher in patients with coronary atherosclerotic heart disease (P < 0.05); With the increasing of blood pressure, the score of MMSE showed a decreasing trend. The average scores of MMSE of those patients whose blood pressure above Grade 3 were significantly decreased than those whose blood pressure below Grade 2 (P < 0.05), but the incidence of mild cognitive impairment has no significant difference (P > 0.05); Memory, attention and computational power, abstraction ability and delayed recall of the selected patients were significantly decreased. Conclusion: Patients with hypertension,coronary atherosclerotic heart disease are prone to mild cognitive impairment; There is a close relation between hypertension and cognitive impairment.