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A SYSTEMATIC REVIEW OF SUPERIORITY TRIALS TO ELUCIDATE THE CONCEPT OF SUPERIORITY MARGIN

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Objective:Progress towards superiority trial design and analysis has been slow. A statistically significant result may not be clinically relevant. In this study, we aimed to show that overpowered trials show… Click to show full abstract

Objective:Progress towards superiority trial design and analysis has been slow. A statistically significant result may not be clinically relevant. In this study, we aimed to show that overpowered trials show statistical significance sans clinical relevance.Design and method:We did a systematic revie

Keywords: trials elucidate; elucidate concept; superiority trials; systematic review; review superiority; superiority

Journal Title: Journal of Hypertension
Year Published: 2019

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