LAUSR

Objective: Recent work have emphasized the importance of adaptive cardiac emodelling (Plos One, IJCCRP, Am J Cardiovasc Dis., 2021). In addition to hemodynamic stress in hypertension, novel cardiac imaging have shown that stressed heart morphology (SHM: basal septal hypertrophy, the early imaging biomarker in hypertension, J Applied Physiol 2019) could be affected by emotional stress and aortic stenosis (B Press Monitor 2020, ATCS 2021). Design and method: The aim of the study was to explore the potential effect of chronic emotional and mental overdrive in addition to chronic hemodynamic stress due to chronic hypertension. Therefore, we planned to determine imaging data as well as neurologic stress scores in SHM and compare them in terms of geometric details and severity of stress scores. Results: SHM was diagnosed in 50 chronic patients with systemic hypertension using the universal criteria (thicker than 1.4 cm septal base on the parasternal long axis). Then, we decided to detect quantitative scores of neurologic stress for all patients of the study group. The patients with SHM with irregular septal basal emodelling with septal bulging were associated with high neurologic stress score, while the other SHM patients with regular emodelling had lower score (p < 0.05). Conclusions: SHM seems like a quite complex phenomenon which possibly affected by emotional and mental overdrive beyond pure hemodynamic stress due to hypertension. Complex imaging findings also are consistent with adaptive phase SHM (J Clinic Med 2022, J of Hypertension 2022) showing irregular nature of human SHM which is likely to depend on cognitive function compared to regular emodelling in animals.