LAUSR

Objective: To describe proportion of patients with uncontrolled hypertension (HTN) receiving bisoprolol additionally to perindopril/indapamide/amlodipine single-pill combination (SPC) and predictors of its prescription in patients included in the TRICOLOR study. Design and method: TRICOLOR (NCT03722524) was a multicenter, open-label, 3-month observational study that included 1 247 patients with uncontrolled HTN despite receiving antihypertensive treatment, who were initiated with the SPC in outpatient settings in Russia. Univariate logistic regression analysis was performed to describe the relationship between clinically relevant baseline (BL) patients’ characteristics and bisoprolol on-treatment status at the inclusion in the study. Results: At baseline 19.1% of patients (n = 238) were receiving bisoprolol. Mean age of the patients receiving bisoprolol was 60.3 ± 9.6 years, 59.2% (n = 141) of them were female. Patients receiving bisoprolol at BL had a significantly longer duration (p< 0.0001) and more severe HTN (p = 0.001) as well as more frequent concomitant comorbid status (p < 0,0001) compared to those not receiving bisoprolol at BL. They were less frequently male (40.8% vs 61.2%; p < 0.0001), had significantly higher body mass index (BMI) (30.4 ± 5.1 vs 28.8 ± 4.4 kg/m2; p < 0.0001). Statistically significant, but not clinically meaningful, relationship between bisoprolol on-treatment status at BL and BMI (OR = 1.07, 95% CI 1.03 to 1.10), waist circumference (OR 1.03, 95% CI 1.02 to 1.04), heart rate (OR 1.02, 95% CI 1.00 to 1.04) and duration of HTN (OR 1.04, 95% CI 1.02 to 1.06) were revealed. However, presence of dyslipidemia (OR 1.72, 95% CI 1.20 to 2.51), left ventricular hypertrophy (OR 1.98, 95% CI 1.25 to 3.30), chronic heart failure (OR 2.23, 95% CI 1.62 to 3.08;), coronary artery disease (OR 2.66, 95% CI 1.90 to 3.70), a history of myocardial infarction (OR 3.15, 95% CI 1.90 to 5.14), and a history of stroke / transient ischemic attack (OR 2.53, 95% CI 1.37 to 4.53) significantly increased the likelihood of being on bisoprolol at the inclusion in the study. Conclusions: In the post-hoc analysis of the TRICOLOR study, patients receiving bisoprolol in addition to SPC at BL had predominantly more severe HTN, with presence of concomitant cardiovascular disease.