LAUSR

Objective: Of the study was to investigate the role of remnant cholesterol levels and other lipid parameters levels to the major cardiovascular events (MACE) in hypertensive patients. Design and method: This is a prospective analysis including 637 hypertensive patients (52,6% female) of mean age at the entry: 57,2 ± 13,1 years, mean office systolic/diastolic blood pressure (S/DBPo): 152,3 ± 19,1/94,4 ± 11,83 mmHg, mean office heart rate (HRo): 76,0 ± 12 beats/min, treated or newly diagnosed untreated. The median follow-up period was 9 years. Total cholesterol (TCH), LDL-CH, HDL-CH, Triglycerides (Trg), VLDL-CH were measured at the entry of the study and Remnant cholesterol (RCH) as well as non HDL-CH (nonHDL) were calculated at the entry of the study. Major cardiovascular events (MACE) (myocardial infarction, unstable angina, transient ischemic attack or stroke, peripheral vascular intervention, heart failure events, cardiovascular death) were registered. We estimated the prognostic value of the above mentioned lipids parameters to the MACE. Cox proportional hazard model were employed to determine the prognostic value of lipid parameters. Results: The median follow-up period was 9 years. There were 264 (40,5%) MACE at the end of the study. Table Cox regression statistical analysis Lipids (mg/dl) p value HR 95%cl TCH NS 0.998 0.995–1,000 LDL-CH 0.023 0.997 0.994–1,000 HDL-CL 0.031 0.990 0.981–0.999 VLDL-CH NS 0.993 0.965–1,021 Trg 0.001 1.002 1.001–1.003 RCH 0.002 1,010 1.004–1.016 nonHDL-CH NS 1,000 0,997–1,002 TCH = total cholesterol, Trg=triglycerides, RCH= remnant cholesterol Conclusions: Remnant cholesterol as well as triglycerides serum levels, were the major predictors of MACE, greater than the prognostic value to MACE of LDL-CH and HDL-CH, while total and non HDL CH did not have any predictor value to MACE in hypertensive patients in a follow up of 9 years.