LAUSR

STUDY DESIGN Randomized trial. OBJECTIVE To implement an algorithm enabling the automated segmentation of spinal muscles from open MR images in healthy volunteers and patients with adult spinal deformity (ASD). SUMMARY OF BACKGROUND DATA Understanding spinal muscle anatomy is critical to diagnosing and treating spinal deformity. Muscle boundaries can be extrapolated from medical images using segmentation, which is usually done manually by clinical experts and remains complicated and time-consuming. METHODS Three groups were examined: two healthy volunteer groups (N = 6 for each group) and one ASD group (N = 8 patients) were imaged at the lumbar and thoracic regions of the spine in an upright open MRI scanner while maintaining different postures (various seated, standing and supine). For each group and region, a selection of regions of interest (ROIs) were manually segmented. A multi-scale pyramid 2D convolutional neural network was implemented to automatically segment all defined ROIs. A five-fold cross-validation method was applied and distinct models were trained for each resulting set and group and evaluated using Dice coefficients calculated between the model output and the manually segmented target. RESULTS Good to excellent results were found across all ROIs for the ASD (Dice coefficient > 0.76) and healthy (dice coefficient > 0.86) groups. CONCLUSION This study represents a fundamental step toward the development of an automated spinal muscle properties extraction pipeline, which will ultimately allow clinicians to have easier access to patient-specific simulations, diagnosis and treatment.Level of Evidence: 2.